EFFECTS OF RADIOPROTECTIVE COMPOUNDS ON TOXICITY OF NITROGEN MUSTARD (in Italian)
Journal Article
·
· Ricerca sci.
OSTI ID:4166061
The protective action of radioprotective compounds on the toxicity of nitrogen mustard in mice (LD/sub 99//6 days) was studied. The maximum protective action was observed by employing diethyldithiocarbamate (Na salt), a drug of the chelating agents group, and it has been progressively weaker with metabolic depressants, polyalcohols, and antioxidizing drugs. No action was observed by employing sulfihydrillic compounds, hormones and amines. On the basis of the knowledge on the action mechanism of alkylating agents there is discussed the mode of the protective activity developed by certain drugs, which are considered as typical radioprotective compounds, pointing out some analogies between action mechanisms of alkylating agents and of ionizing radiations. (auth)
- Research Organization:
- Universita, Padua
- NSA Number:
- NSA-14-021259
- OSTI ID:
- 4166061
- Journal Information:
- Ricerca sci., Journal Name: Ricerca sci. Vol. Vol: 30
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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