Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion

Journal Article · Tue Apr 01 00:00:00 EDT 1975 · Circulation, v. 51, no. 4, pp. 641-645

DOI:https://doi.org/10.1161/01.CIR.51.4.641· OSTI ID:4163362

Strauss, H W; Harrison, K; Langan, J K; Lebowitz, E; Pitt, B

Following intravenous administration, the myocardial concentration of tracer thallium-201, potassium-43, and rubidium-81 were determined in mice; thallium was present in the greatest concentration in the myocardium (2.08 percent compared 1.25 percent for potassium and 1.15 percent for rubidium at 10 minutes). The regional myocardial distribution of thallium-201 was determined in dogs under conditions of normal flow, and total occlusion, and compared with potassium-43 (r = 0.97). The regional distribution of thallium-201 was compared to microspheres under conditions of partial occlusion and reactive hyperemia (r = 0.97). Thallium-201 was evaluated in a series of phantom scans, which demonstrated that the low energy x ray of thallium was suitable for imaging. These results suggest that thallium-201 can be used for the evaluation of the distribution of regional myocardial perfusion. (auth)

• Research Organization: Johns Hopkins Medical Institutions, Baltimore
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-003397
• OSTI ID: 4163362
• Journal Information: Circulation, v. 51, no. 4, pp. 641-645, Journal Name: Circulation, v. 51, no. 4, pp. 641-645; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

*MYOCARDIUM-- SCINTISCANNING
*POTASSIUM 43-- UPTAKE
*RUBIDIUM 81-- UPTAKE
*SCINTISCANNING-- THALLIUM 201
*THALLIUM 201-- UPTAKE
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
CHROMIUM 51
COMPARATIVE EVALUATIONS
DOGS
INTRAVENOUS INJECTION
MICE
MICROSPHERES
N48720 --Life Sciences--Nuclide Kinetics & Toxicology--Animals
N48830* --Life Sciences--New Tracer Techniques--Other
PERFUSED ORGANS
PHANTOMS
STRONTIUM 85