Limitations of /sup 201/Tl myocardial perfusion scintigrams

Journal Article · Fri Oct 01 00:00:00 EDT 1976 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.54.4.640· OSTI ID:7312683

Mueller, T M; Marcus, M L; Ehrhardt, J C; Chaudhuri, T; Abboud, F M

The reliability of myocardial perfusion scintigrams with thallium-201 (201Tl) for detecting areas of hypoperfusion was assessed in 16 closed-chest dogs. Variable areas of ischemia were produced either by occluding or stenosing the left anterior descending coronary artery. Cardiac scintigrams taken in four projections were compared with regional myocardial perfusion maps. Segmental concentrations and segmental perfusions were quantitated by counting the emissions from /sup 201/Tl and the microspheres in each of 96 segments of the left ventricle. In addition, studies with a phantom were performed. The results indicate: (1) The emissions from /sup 201/Tl and from microspheres correlated well in ischemic segments (r = 0.93 +- SE 0.02). (2) Seven of twelve ischemic hearts had definitely abnormal scintigrams and in each of these the hypoperfused zone was greater than 4.9 grams and perfusion was decreased by more than 45 percent. (3) In the phantom, abnormal scintigrams could be detected in the presence of lesser deficits than in the dogs. The limitation of the thallium perfusion scintigrams will be the inconsistent detection of small perfusion deficits.

• Research Organization: Univ. of Iowa, Iowa City, IA (United States)
• OSTI ID: 7312683
• Journal Information: Circulation; (United States), Vol. 54:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ISCHEMIA
DIAGNOSIS
MYOCARDIUM
SCINTISCANNING
THALLIUM 201
DOGS
PERFUSED ORGANS
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HEMIC DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics