DNA SYNTHESIS IN IRRADIATED HAIR FOLLICLES OF THE MOUSE

Journal Article · Sun May 01 04:00:00 EDT 1960 · Radiation Research

DOI:https://doi.org/10.2307/3570979· OSTI ID:4162294

Cattaneo, S M; Quastler, H; Sherman, F G

>Hair follicles in mice were induced to produce hair by plucking and were then x irradiated with 200, 800, or 3000 rads. DNA synthesis in the proliferating matrix cells of irradiated hair follicles was studied at times from immediately after to 48 hours after irradiation, by the method of labeling with tritiated thymidine and autoradiography. Reduction of thymidine incorporation commences immediately after irradiation and amounts to about 50% within 30 minutes with the two higher doses, possibly also with 200 rads. This is an effect on cells in the process of synthesizing DNA at the time of irradiation. R is followed by a slow decline which may be of complex nature. Resumption of DNA synthesis occurs within 12 hours post-irradiation, even with the highest dose used, and considerably precedes resumption of mitotic activity. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y.; Brown Univ., Providence
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-013637
• OSTI ID: 4162294
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 12
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
HAIR
HAIR FOLLICLES
LABELLED COMPOUNDS
MICE
MITOSIS
NUCLEIC ACIDS
ORGANIC NITROGEN COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOAUTOGRAPHY
SKIN
THYMIDINE
TISSUES
TRITIUM
X RADIATION