Dynamic studies with /sup 99m/Tc-HEDP in normal subjects and in patients with bone tumors

Journal Article · Wed Oct 01 04:00:00 EDT 1975 · J. Nucl. Med., v. 16, no. 10, pp. 886-890

OSTI ID:4162218

Citrin, D L; Bessent, R G; McGinley,; Gordon, D

Blood clearance, urinary excretion, and spinal uptake of /sup 99m/Tc- HEDP (ethane-hydroxydiphosphonate) were measured in ten normal control subjects. Blood clearance from 15 min is biexponential. Approximately 70 percent of the administered activity was excreted in the urine within 6 hr of injection. Spine- to-background ratios rise sequentially with time. Net normal bone uptake rises little after 2 hr and improved visualization of the normal skeleton thereafter is due to reduction of blood background activity. In 13 patients with bone tumors, direct measurement of diphosphonate uptake by the tumor-involved and corresponding normal bone showed a continued rise in diphosphonate levels in the tumor-involved bone due to increased metabolic activity. (auth)

• Research Organization: Royal Infirmary, Glasgow
• NSA Number: NSA-33-001040
• OSTI ID: 4162218
• Journal Information: J. Nucl. Med., v. 16, no. 10, pp. 886-890, Journal Name: J. Nucl. Med., v. 16, no. 10, pp. 886-890; ISSN JNMEA
• Country of Publication: United States
• Language: English

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