Final report on the short term reproductive and developmental toxicity of chlorodibromo-methane (CAS No. 124-48-1) administered in drinking water to sprague-dawley rats. Technical report
The potential toxicity of chlorodibromomethane (CAS No. 124-48-1; CDBM) was evaluated using a short-term reproductive and developmental toxicity screen. This study design was selected to identify the process (development; female reproduction; various somatic organs/processes) that is the most sensitive to chlorodibromomethane exposure. A dose-range finding study was conducted at concentrations of 0, 5, 50, 150, and 450 ppm in drinking water in order to select concentrations for the 35-day study. Based on dose-related body weight gain reductions and decreased water consumption, the concentrations for the 35-day study were selected to be 0, 50, 150, and 450 ppm. One group of male rats (10 per group) and two groups of female rats, designated as Group A (peri-conception, 10 per group) and Group B (gestational exposure, 13 per group), were used at each dose level. Control animals received deionized water, the vehicle.
- Research Organization:
- R.O.W. Sciences, Inc., Gaithersburg, MD (United States)
- OSTI ID:
- 415855
- Report Number(s):
- PB-97-111728/XAB; CNN: Contract NIEHS-N01-ES-15323; TRN: 63311573
- Resource Relation:
- Other Information: PBD: Sep 1996
- Country of Publication:
- United States
- Language:
- English
Similar Records
The potential reproductive, neurobehavioral and systemic effects of soluble sodium tungstate exposure in Sprague-Dawley rats
Dose-response toxicity studies on tributoxyethyl phosphate orally administered to Sprague-Dawley rats