Influence of the lambda prophage on the action of the inducible inhibitor of postirradiation DNA degradation
Journal Article
·
· Radiat. Res., v. 63, no. 3, pp. 553-559
OSTI ID:4158388
Early observations on the inducible inhibitor of postirradiation DNA degradation involved cells of Eschericia coli which carried either prophage or defective prophage. The question as to whether the prophage element is essential can be answered by observing the induction of inhibition in cells which (a) carry the prophage and can be induced or do not have the prophage and (b) carry the prophage but can not be induced. The strains used are AB1157 and AB1157$gamma$/ sub ref/; AB2463(recA$sup -$) and AB2463$gamma$ /sub ref/; AB2494(lex$sup -$) and AB2494$gamma$/sub ref/. The results indicate that, while the presence of an inducible prophage does modify the postirradiation DNA degradation, it is not essential; inhibition occurs in its absence. On the other hand a prophage in a cell where induction is absent or minimal does not confer the property of inhibition. The inducible inhibitor is therefore a property with characteristics similar to phage induction but not the same as phage induction. (auth)
- Research Organization:
- Pennsylvania State Univ., University Park
- NSA Number:
- NSA-33-007423
- OSTI ID:
- 4158388
- Journal Information:
- Radiat. Res., v. 63, no. 3, pp. 553-559, Journal Name: Radiat. Res., v. 63, no. 3, pp. 553-559; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*BACTERIOPHAGES
*DNA-- BIOLOGICAL RADIATION EFFECTS
*ESCHERICHIA COLI-- BIOLOGICAL RADIATION EFFECTS
*NUCLEIC ACID DENATURATION-- RADIOINDUCTION
560112* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Biochemicals--In Microorganisms
GAMMA RADIATION
IRRADIATION
N48120* --Life Sciences--Radiation Effects on Biochemicals-- In Microorganisms
N48310 --Life Sciences--Radiation Effects on Microorganisms--Basic Studies
RESPONSE MODIFYING FACTORS
*DNA-- BIOLOGICAL RADIATION EFFECTS
*ESCHERICHIA COLI-- BIOLOGICAL RADIATION EFFECTS
*NUCLEIC ACID DENATURATION-- RADIOINDUCTION
560112* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Biochemicals--In Microorganisms
GAMMA RADIATION
IRRADIATION
N48120* --Life Sciences--Radiation Effects on Biochemicals-- In Microorganisms
N48310 --Life Sciences--Radiation Effects on Microorganisms--Basic Studies
RESPONSE MODIFYING FACTORS