EFFECT OF ADRENAL HORMONES ON THE RADIATION SENSITIVITY OF CHROMOSOMES OF THE CORNEA EPITHELIAL CELLS (in Russian)
Journal Article
·
· Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals
OSTI ID:4158257
Chromosomal rearrangement in corneal cells was investigated in adrenalectomized mice exposed to 25, 50 or 100 r of x-rays. The formation of bridges and fragments in the chromosomes during anaphase and early telophase was taken as the criterion of radiation damage. Bilateral adrenalectomy was performed in two steps, 24 hr apant, and sham-operated animals served as controls. The same frequency of rearrangements was found between normals and adrenalectomized mice (0.05 to 0.06%), and also between normal irradiated animals and sham-operated irradiated animals. The frequency of rearrangements increases with the irradiation dose, particularly in the adrenalectomized animals, eventually reaching a 200-fold value of the normal frequency. At every irradiation dose, adrenalectomy was found to increase the damaging effects of radiations on the chromosome structure by a factor of two. The relation between the increase in mitotic activity due to adrenalectomy and the increase in mitotic activity due to adrenalectomy and the increase in the frequency of chromosome rearrangements is discussed. Emphasis is given to the role played by the adrenal hormones on the radiosensitivity of the organisms. (TTT)
- Research Organization:
- Inst. of Cytology and Genetics, Academy of Sciences, Siberian SSR
- NSA Number:
- NSA-18-001395
- OSTI ID:
- 4158257
- Journal Information:
- Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 152; ISSN DANKA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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