EFFECTS OF CHELATING AGENTS ON RADIO-IRON ABSORPTION AND DISTRIBUTION IN RATS IN VIVO
Effects of ethylenediaminetetraacetate (EDTA), citrate, ascorbate, succinate, and sorbitol on the absorption and postabsorptive distribution of Fe/ sup 59/Cl/sub 3/ in the rat where studied, using an isolated loop technique. Citrate most effectively promoted iron absorption, with ascorbate, EDTA, and succinate following in that order. Sorbitol seemed without effect. Control animals with access to food until time of experiment absorbed more radioiron than did fasted controls. Partial trypsin hydrolysis permitted demonstration that succinate-exposed gut cells most avidly retained iron, while EDTA led to least cellular retention. Postabsorptive distribution among blood, liver, spleen, long bones, kidneys, and urine was unremarkable except that EDTA promoted marked radioiron urinary excretion. EDTA may pass through the gut wall as an intact iron chelate. A pattern of actions during iron absorption is proposed for EDTA, citrate, ascorbate, and succinate. (auth)
- Research Organization:
- Kansas State Univ., Manhattan
- NSA Number:
- NSA-18-001346
- OSTI ID:
- 4150104
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 205; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BIOLOGY AND MEDICINE
BLOOD
BONES
CHELATES
CITRIC ACID
CYTOLOGY
DIFFUSION
DISTRIBUTION
EDTA
EFFICIENCY
ENZYMES
FOOD
HYDROLYSIS
INTESTINE
IRON 59
IRON CHLORIDES
KIDNEYS
LIVER
MEMBRANES
METABOLISM
QUANTITY RATIO
RATS
SORBITOL
SPLEEN
SUCCINIC ACID
SUGARS
TRYPSIN
URINE
VARIATIONS
VITAMIN C
VITAMINS