QUARTERLY PROGRESS REPORT NO. 36
Technical Report
·
OSTI ID:4146021
The degree of modification of the radiation-induced increases in the adenosine triphosphatase activity of the spleen and thymus glands and decreases in the acetylcholinesterase activity of the small intestines of rats pretreated with various chemical combinations was used as a means of quantitatively determining the radioprotective effect of chemical agents. Data are included on the effects of serotontn, 5,5'dithiobis-(2-nttrobenzoic acid), and combinations of these agents. Progress is reported in a detailed study of the effects of beta -aminoethylisothiuronium on the enzyme systems of mammalian tissues. This study is part of a program designed to extend the available information on the biochemical mechanisms responsible for the radioprotective actions of various sulfur-containing radioprotective agents. Progress is reported in studies on the toxicity of rare-earth oxides and nitrates, and the biological effects of simultaneous exposure to ionizing radiations and rare-earth elements. Fifty-four tissue extracts prepared from bovine thymus, red and yellow bone marrow and porcine spleen, intestinal mucosa, and pancreas were tested for radiotherapeutic activity by administering the material to mice for five days following a lethal exposure to whole-body x irradiation. None of the extracts tested exhibited marked therapeutic effects. Results are tabulated from screening tests on the radioprotective effects of 110 chemical compounds in x-irradiated mice. Seventeen of these compounds exhibited some protective effect. Data are included from pharmacological studies on the radioprotective activity of serotonin and aminoethylisothiuronium. (C.H.)
- Research Organization:
- Chicago. Univ. Air Force Radiation Lab.
- NSA Number:
- NSA-15-001144
- OSTI ID:
- 4146021
- Report Number(s):
- NP-9054
- Country of Publication:
- United States
- Language:
- English
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