THE PHARMACOLOGY OF RADIOPROTECTANT CHEMICALS. GENERAL PHARMACOLOGY OF / cap beta/-MERCAPTOETHYLAMINE
When 100 mg of beta -mercaptoethylamine is administered intravenously to the dog over a period of 5 min a characteristic set of reactions is produced. The most notable of these in the nonanesthetized dog are violent emesis, agitation frequently leading to tonic-clonic convulsions, ataxia and a characteristic swaying movement of the front portion of the body, generalized depression, loss of pain sense, severe hypotension, relative bradycardia, blood- tinged diarrhea, and a mixed stimulation and depression of respiration. Anesthesia prevents the emetic and convulsive components of the reaction but does not affect the cardiovascular changes. The agent produces a delayed, severe, prolonged hypotension. The possibility is discussed that the physiological changes produced by this agent may contribute to its radioprotective potential. 27 references. (auth)
- Research Organization:
- Walter Reed Army Medical Center, Washington, D.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-023865
- OSTI ID:
- 4145863
- Journal Information:
- Radiation Research, Vol. Vol: 13; Other Information: Orig. Receipt Date: 31-DEC-60
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
ANESTHESIA
BEHAVIOR
BIBLIOGRAPHY
BIOCHEMISTRY
BLOOD CIRCULATION
BLOOD VESSELS
CHEMICAL REACTIONS
DIFFUSION
DISEASES
DOGS
DRUGS
HEART
INTESTINE
LUNGS
MEA
MEDICINE
METABOLISM
MUSCLES
NERVOUS SYSTEM
ORGANIC SULFUR COMPOUNDS
PHARMACOLOGY
PHYSIOLOGY
RADIATION PROTECTION
REACTION KINETICS
STOMACH
VARIATIONS