CARCINOMA OF THE MAXILLARY SINUS FOLLOWING THOROTRAST INSTILLATION. Report of 3 Cases

Journal Article · Thu Sep 01 00:00:00 EDT 1960 · Cancer

DOI:https://doi.org/10.1002/1097-0142(196009/10)13:5<967::AID-CNCR2820130516>3.0.CO;2-Z· OSTI ID:4145306

Kligerman, M; Lattes, R; Rankow, R

Three cases of carcinoma of the maxillary sinus 10, 18, and 21 years after the instillation of thorium dioxide (Thorotrast) into the maxillary sinus are reported. Histologically, one was an adenocarcinoma, one was a squamous cell carcinoma, and one was a mucoepidermoid carcinoma. A cause and effect relationship between the substance used and the production of the cancer appears highly probable. These cases add to the existing accumulated evidence that Thorotrast or otherrelated radioactive substances should not be used as a diagnostic medium since their persistence in the form of colloidal particles in the tissues over long periods represents a definite hazard for a possible carcinogenic effect. (auth)

• Research Organization: Columbia Univ., New York
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-023950
• OSTI ID: 4145306
• Journal Information: Cancer, Journal Name: Cancer Vol. Vol: 13
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACCIDENTS
BIOLOGY AND MEDICINE
CANCER
CARCINOGENESIS
COLLOIDS
CYTOLOGY
DIAGNOSIS
LIFETIME
MAN
MEDICINE
PARTICLES
RADIOGRAPHY
RADIOISOTOPES
THORIUM OXIDES
THOROTRAST
TISSUES
USES