HISTOPATHOLOGY IN ALBINO MICE AND RHESUS MONKEYS INFECTED WITH IRRADIATED CERCARIAE OF SCHISTOSOMA JAPONICUM

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Zeitschrift fuer Tropenmedizin und Parasitologie (West Germany)

OSTI ID:4143478

Hsu, H F; Davis, J R; Li Hsu, S Y; Osborne, J W

A comparative study was made on the histopathology of mice and monkeys infected once or several times with cercariae of the J strain which had been x- irradiated with different doses (1700 to 4800 r). Resulis showed that the fate of the migrating schistosomula in mice varies with the amount of irradiation. With x-ray exposures of destroyed in liver; with 12000 r the skin, lungs, and liver played nearly equal roles in schistosomulic extinction; with 24000 r the schistosomula were usually destroyed in skin, seldom in lungs, but never in liver; and with 48000 r all the schistosomula perished in the skin. The differences in timing, rate, and site of schistosomulic destruction in mice between a group infected once with x-irradiated cercariae and another group infected twice with the same kind of cercariae were not significant at 3000 r or 6000 r, but were significant at 12000 r and 48000 r. However, if the reinfection was given four times, similar differences were significantly shown even with mice infected with cercariae exposed to 3000 r. The effects produced by the repeated irfections were demonstrated as and early appearance and increased intensity of the inflammatory reaction. In extreme cases the site of schistosomulic destruction shifted from liver to lung and skin. The fate of migrating schistosomula and their histopathology in rhesus monkeys infected either once with cercariae exposed to 3000 r and 48000 r or five times with cercariae exposed to 3000 r was similar to those in mice. The results showed that the secretory ability of the cephalic glands of the cercariae inoculated was not injured up to 48000 r because it was demonstrated that they could pass through the epidermis and reach the dermis and subcutis. However, high doses may have impaired their ability to produce enzyries necessary for penetration of cutaneous blood vessels, explaining why they were eventually destroyed extravascularly in the derriis and subcutis. Similarly, irradiation might inhibit schistosomu lic metabolism and growth in lung and interfere with digestion and assimilation of nourishment in liver. (BBB)

• Research Organization: Univ. of Iowa, Iowa City
• NSA Number: NSA-18-005113
• OSTI ID: 4143478
• Journal Information: Zeitschrift fuer Tropenmedizin und Parasitologie (West Germany), Journal Name: Zeitschrift fuer Tropenmedizin und Parasitologie (West Germany) Vol. Vol: 14; ISSN ZTMPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD VESSELS
CERCARIA
CYTOLOGY
DISTRIBUTION
EMBRYOS
ENZYMES
EPIDERMIS
GLANDS
LIVER
LUNGS
METABOLISM
MICE
MONKEYS
PARASITES
PHYSIOLOGY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
SCHISTOSOMA
SKIN
SUBCUTANEOUS
VARIATIONS
X RADIATION