QUANTITATIVE POPULATION GENETICS OF MICE UNDER IRRADIATION. Progress Report for July 1, 1959-June 30, 1960

Technical Report · Fri Jul 01 04:00:00 EDT 1960

OSTI ID:4143461

Green, E L

Two groups of populations of mice are being propagated, generation after generation, under selected levels of gonadal irradiation and of inbreeding. The objective is to assess the effects, if any, of radiation and inbeeding on several characteristics which measure biological fitness. One group of populations, called genetically homogeneous, ls descended from a single pair of an inbred strain of mice. The other group, called genetically heterogeneous, is descended from four pairs, one from each of four inbred strains, which were crossed to produce double-cross hybrids. In each group, there are 12 populatlons with 16 mated pairs per generation. The 12 populations represent all combinations of three levels of radiation (0, 50, 100 r) and four levels of inbreeding. Samples of each population are studied at intervals of from one to four generations for reproductive performance, longevity, activity, radiation resistance, and developmental characteristics. In addition, three associated experiments are in progress, one on the question of genetic extinction due to radiation, one on selection for radiation resistance, and one on the comparative radiosensitivity of mice differing by a single gene at a known locus. (auth)

• Research Organization: Roscoe B. Jackson Memorial Lab., Bar Harbor, Me.
• NSA Number: NSA-14-025238
• OSTI ID: 4143461
• Report Number(s): TID-6278
• Country of Publication: United States
• Language: English

Related Subjects

AGE
BEHAVIOR
BIOLOGY AND MEDICINE
CHROMOSOMES
GENETICS
GONADS
IRRADIATION
MICE
POPULATIONS
RADIATION EFFECTS
RADIOSENSITIVITY