Radionuclide uptake studies of bone: a quantitative method of evaluating the response of patients with Paget's disease to diphosphonate therapy

Conference · Sat Nov 01 04:00:00 EST 1975 · Radiology, v. 117, no. 2, pp. 365-369

OSTI ID:4142786

Goldman, A B; Braunstein, P; Wilkinson, D; Kammerman, S

In order to evaluate and quantitate the therapeutic efficacy of disodium etridonate (EHDP) in the treatment of Paget's disease, a prospective double-blind study was instituted. Subjects received either placebo, low-dose EHDP, or high- dose EHDP and were evaluated prior to therapy and 6 months later. Bone scans were performed with /sup 99m/Tc or $sup 18$F and radioisotopic uptake studies were conducted. The results were correlated with clinical improvement, biochemical parameters, and radiographic skeletal surveys, and indicate that the radioisotopic uptake studies are both a sensitive and reproducible means of evaluating the degree of response to EHDP. (auth)

• Research Organization: New York Univ., NY
• NSA Number: NSA-33-001076
• OSTI ID: 4142786
• Conference Information: Journal Name: Radiology, v. 117, no. 2, pp. 365-369
• Country of Publication: United States
• Language: English

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