METABOLISM OF Zn$sup 65$ IN THE RAT--CHRONIC ADMINISTRATION STUDIES AND AGE EFFECTS

Technical Report · Mon Jan 25 04:00:00 EST 1960

OSTI ID:4142379

Ballou, J E

Analysis of daily excretion during and following chronic feeding of Zn/ sup 65/ indicated approximately 50 to 60 per cent of the ingested isotope was absorbed from the gastrointestinal tract. Tissue retention of Zn/sup 65/ deposited during chronic exposure was nearly the same as that found earlier in single administration studies. This agreement of results further supports earlier estimates of the hazard of Zn/sup 65/. The relatively high concentration and continued accumulation of Zn/sup 65/ in bone and prostate gland throughout the feeding period suggested these organs as the critical organs for MPC calculations. Accumulation in the total body appears to be critical, however, due to the greater absorption of the decay energy in the larger organism and the lower permissible dose rate recommended for total body irradiation. The MPC calculated employing total body as critical organ was 3 x 10/sup -3/ ation c/ml, using prostate the value was 3 x 10/sup -3/ ation c/ml and for bone a value of 1.4 x 10/sup -2/ ation c/ml was obtained. Twenty- four hour retention of gavage fed Zn/sup 65/ by immature rats was as much as 5.5 times that of the adult. Absorption after weaning dropped abruptly to the adult level. Fetal tissue concentrations of Zn/sup 65/ generally exceeded those of the dam fed during pregnancy; however, totul Zn/sup 65/ in the dam was greater than that in the total litter. Some suggestion of longer retention in the litter was found over a seven day retention period after Zn/sup 65/ feeding was discontinued. (auth)

• Research Organization: General Electric Co. Hanford Atomic Products Operation, Richland, Wash.
• DOE Contract Number: AT(45-1)-1350
• NSA Number: NSA-14-018733
• OSTI ID: 4142379
• Report Number(s): HW-63047
• Country of Publication: United States
• Language: English

Related Subjects

ABSORPTION
AGE
BIOLOGY AND MEDICINE
BODY
BONES
DECAY
DEPOSITS
DIET
DIFFUSION
FETUSES
FOOD
GLANDS
INTESTINE
IRRADIATION
LABELLED COMPOUNDS
METABOLISM
NUMERICALS
PREGNANCY
PROSTATE
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOACTIVITY
RATS
STANDARDS
STOMACH
TISSUES
URINE
VARIATIONS
ZINC 65