EFFECT OF X-IRRADIATION ON THE NEUROSECRETORY SYSTEM

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Federation Proc., Transl. Suppl.

OSTI ID:4140496

Maiorova, V F

Exposure of rats to minimal lethal doses of whole-body x irradiation causes changes in the secretory function of the nerve cells of the hypothalamus. During the first few hours after irradiation, there is intensification of the synthesis, and of the release into the blood, of the neurosecretory substance elaborated by the neurons of the supraoptic and paraventricular nuclei. Twenty- four hours after irradiation, the neurosecretory activity of the hypothalamohypophyseal system has returned to normal. A comparison of the alterations in the neurosecretory activity of the hypothalamo-hypophyseal system with the coincident changes in the blood ACTH levels gives reason to assume an interrelationship between the neurosecretion of this system and the adrenal corticotropic function of the adenohypophysis. Evidently, the hypothalamo- hypophyseal systein responds to the absence of pituitary ACTH by increased neurosecretory activity. (auth)

• Research Organization: Inst. of Experimental Endocrinology, Moscow
• NSA Number: NSA-18-003529
• OSTI ID: 4140496
• Journal Information: Federation Proc., Transl. Suppl., Journal Name: Federation Proc., Transl. Suppl. Vol. Vol: 22
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACTH
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD
BODY
GLANDS
HORMONES
HYPOTHALAMUS
LETHAL DOSE
METABOLISM
NERVOUS SYSTEM
PITUITARY GLAND
RADIATION EFFECTS
RATS
X RADIATION