PLASMA VALUES AFTER ORAL CALCIUM-45 AND STRONTIUM-85 AS AN INDEX OF ABSORPTION
Journal Article
·
· Clinical Science (England) Changed to Clin. Sci. Mol. Med.
OSTI ID:4137481
Plasma values after intravenous andd oral doses of Sr/sup 85/ and C/sup 45/ were used to permit a more rapid determination of absorption. Patients received intravenous doses of 0.1 to 0.4 mu C/kg of Sr/sup 85/ or Ca/sup 45/ or both, as the chloride. The Sr/sup 85/ was carrier free; Ca/sup 46/ contained a fraction of a mg of stable Ca per dose. Oral doses were administered with 25 mg of stable Sr as carrier for Sr/sup 85/ and 25 mg of stable Ca as carrier for Ca/ sup 45/. Plasma values of Sr/sup 85/, and Ca/sup 45/ were compared in 44 patients after 76 intravenous and 71 oral doses, with particular emphasis on values obtained the first day. In patients receiving several intravenous doses, plasma values were reproducible despite differences in treatment. The values of 1, 4, 8, and 24 hours depended chiefly on passage from plasma into other body compartments, the influence of urinary excretion in lowering Sr/sup 85/ plasma values becoming evident at 24 hours. Absorption was essentially complete in 4 hours. The percentage of radioisotope absorbed could be determined from plasma values of Sr/sup 85/ and Ca/sup 45/ as well as from stool values. When absorption was low, determination from plasma was more accurate. In general, agreement between absorption calculated by the two methods was good. The average difference between values determined from plasma and stool was 0.99 with a standard error of 0.93. The Sr/sup 85/ absorption, as estimated from the 8 and 24 hour values, was 45-7% of Ca/sup 85/ absorption on a low Ca diet and 55-6% on a high Ca diet. The addition of Ca to a low Ca diet, thus, caused a greater relative decrease in the absorption of Ca/sup 45/ than of Sr/sup 85/. The Sr/sup 85//Ca/sup 45/ ratios after 1 hour were significantly lower than after 4 hours on both high and low Ca diets. On a low Ca diet, only about 1/3 as much Sr/sup 85/ was absorbed as Ca/sup 45/ in the first hour, although by 4 hours about 1/2 as much was absorbed. (BBB)
- Research Organization:
- Veterans Administration Hospital, Hines, Ill.
- NSA Number:
- NSA-18-004978
- OSTI ID:
- 4137481
- Journal Information:
- Clinical Science (England) Changed to Clin. Sci. Mol. Med., Journal Name: Clinical Science (England) Changed to Clin. Sci. Mol. Med. Vol. Vol: 25; ISSN CSCIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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