BIOCHEMICAL CHANGES IN TUMOR CELLS AFTER TREATMENT WITH X RAYS, IODOACETATE, HYDROGEN PEROXIDE, AND ETHYLENIMINOBENZOQUINONE (in German)
Results are reported from biochemical investigations on tumor cells after treatment with various physical and chemical agents. If the effects of x rays, iodo-acetate, H/sub 2/O/sub 2/, and several ethyleneimino-benzoquinones on the carbchydrate metabolism are compared, very similar mechanisms of action are observed. These four agents inhibit the dehydrogenation of triosephosphate; but in the case of iodoacetate. an inactivation of triosephosphatedehydrogenase seems to be the reason for this inhibition. In irradiated cells, however, this enzyme is not inactivated, the delay of dehydrogenation being caused mainly by a loss of DPN. After application of cytostatic agents and H/sub 2/O/sub 2/, a similar mechanism can be suggested although both agents are also able to block this enzyme. On the other hand, the reaction of the DNA-synthesis is different. Here a much greater sensitivity to x rays and to cytostatic agents than in the case of glycolysis is observed. lodo-acetate, however, inhibits DNA-synthesis in the same range of concentrations in which the glycolysis is blocked. (auth)
- Research Organization:
- Universitats-Frauenklinik, Hamburg
- NSA Number:
- NSA-14-025327
- OSTI ID:
- 4136717
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 2
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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