Determination of Radiation-induced Mutation Rates of Recessive Lethal Alleles in Saccharomyces
An attempt to determine radioinduced mutation rates of specific genes to recessive lethal alieles was undertaken by comparing the survival rates of irradiated diploid cells heterozygous for one recessive lethal allele (S ⁺ 1) with those of diploid cells homozygous for the corresponding vital alleles (S⁺+). Two out of three investigated +/1 strains did show a significantly increased x-ray sensitivity as compared with the values obtained for the parental +/+ strain. Mutation rates of 0.15 and 0.25 were calculated. The occurrence of extremely high mutation rates to recessive lethal alleles in Saccharomyces was thus confirmed. (P.C.H.)
- Research Organization:
- Freie Universitat, Berlin
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-005063
- OSTI ID:
- 4135594
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4908 Vol. 200; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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