RECOVERY FROM RADIATION-INDUCED TOLERANCE TO HOMOLOGOUS TUMOR
The recovery of transplantation immunity of sublethally irradiated LAF/ sub 1/ mice to DBA lynnphosarcoma P-388 ascites cells was studied under several condition. The time of recovery was not advanced by isologous bone marrow transplantation but was considerably advanced by transplantation of spleen cells from donors 2 to 3 week old. Pretreatment with endotoxin or colchicine produced an advance in gramulocyte. and to less extent in lymphocyte recovery, without advancing recovery of the ability to reject the homotransplant. Colchicine treatment, in fact, caused a significant delay in the recovery time. Although the recovery ED/sub 50/o with endotoxin treatment was midway between that of controls and colchicine-treated mice, this difference was too small for significance at a probability of 0.05. (auth)
- Research Organization:
- National Cancer Inst., Bethesda, Md.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-001296
- OSTI ID:
- 4135534
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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