EFFECTS OF HEAVY HIGH ENERGY CHARGED PARTICLES. II. PRIMARY ATYPICAL EPITHELIAL HYPERPLASIA IN MOUSE SKIN AFTER EXPOSURE TO 10 Mev PROTONS, 20 Mev DEUTERONS, OR 40 Mev $alpha$-PARTICLES

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med.

OSTI ID:4132828

Lippincott, S W; Jesseph, J E; Baker, C P; Calvo, W G; Jansen, C R; Rai, K R; Alcober, V

The direct effects of ionizing particle bombardment upon mouse epidermis were investigated using an external beam of accelerator-produced nronoenergetic, heavy, ionizing particles: 10-Mev protons, 20-Mev deuterons, and 40-Mev alpha particles. The arrangement was such that a cylinder of skin was bombarded with essentially uniform ionization limited to a total depth of 1-2 mm. Within 20 days after bombardment with each of the three types of particles, there developed atypical epithelial hyperplasia without underlying vascular or collagen alterations as predisposing factors. In some instances the epidermal lesions resulting from an exposure of 2000 to 5000 rad resembled the type of lesion considered in the skin of man to be carcinoma in situ. (P.C.H.)

• Research Organization: Brookhaven National Lab., Upton, N.Y. and Wake Forest Coll., Winston Salem, N.C.
• NSA Number: NSA-18-008133
• OSTI ID: 4132828
• Report Number(s): BNL-6981; 0003-9985
• Journal Information: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med., Journal Name: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med. Vol. Vol: 76; ISSN ARPAA
• Country of Publication: United States
• Language: English

Related Subjects

ACCELERATORS
ALPHA PARTICLES
BEAMS
BIOLOGY AND MEDICINE
BLOOD VESSELS
CANCER
COLLAGEN
DEUTERONS
ENERGY
EPIDERMIS
IONIZATION
MAN
MICE
PROTONS
RADIATION DOSES
RADIATION EFFECTS
SKIN
THICKNESS
TISSUES