Photocarcinogenesis and persistent hyperplasia in UV-irradiated SENCAR mouse skin

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8668131· OSTI ID:7170043

Strickland, P T

Susceptibility to photocarcinogenesis has been examined in several mouse strains and stocks including SENCAR, CD-1, BALB/c, C3H, C57Bl, and NZB. SENCAR mice are hypersusceptible to tumorigenesis caused by single high dose exposures to ultraviolet (UV) radiation but not by chronic low-dose exposures. SENCAR mice also exhibit an exaggerated and persistent epidermal hyperplasia in response to UV-induced tissue damage. The persistent hyperplasia is apparently due to a sustained proliferation of the epithelial basal cells, rather than to delayed cell differentiation. SENCAR mice did not exhibit persistent hyperplasia following other forms of tissue damage (surgical or thermal). In related studies, the levels of thymine dimers induced in SENCAR epidermis by UV radiation were comparable to those observed in BALB/c epidermis. In addition, no differences were found in the tissue distribution or persistence of thymine dimers in SENCAR and BALB/c skin.

• Research Organization: NCI-Frederick Cancer Research Facility, MD
• OSTI ID: 7170043
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 68; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL TISSUES
ANIMALS
BODY
CARCINOGENESIS
CELL DIFFERENTIATION
CELL PROLIFERATION
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DISTRIBUTION
ELECTROMAGNETIC RADIATION
EPITHELIUM
EXTREME ULTRAVIOLET RADIATION
IMMUNOASSAY
IMMUNOLOGY
IRRADIATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICE
ORGANS
PATHOGENESIS
PYRIMIDINE DIMERS
RADIATIONS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOINDUCTION
RODENTS
SKIN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES