BONE MARROW TRANSPLANTATION IN CLINICAL CASES AND RELATED PROBLEMS, ESPECIALLY EVOLUTION OF TYPE O ERYTHROCYTES ORIGINATING FROM INFUSED BONE MARROW IN PERIPHERAL BLOOD OF RECIPIENTS

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Nippon Ketsueki Gakkai Zasshi (Japan)

OSTI ID:4127669

Miyoshi, K; Shirakami, A

Homologous bone marrow obtained from donors of the same ABO blood-group type or type O was infused intravenously into 22 patients with various diseases, including leukemia, aplastic andemia, granulocytopenia, and multiple metastatic cancer. As preliminary treatment, x rays or Co/sup 60/ gamma radiation (1000-- 15000 r) and cytostatic drugs were given to the cases with leukemia or carcinoma, and adrenocortical steroid hormone was also given in some cases. The number of infused bone marrow cells varied from 20 to 150 x 10/sup 8/, given in 1--6times in each case. No specific side-effects were observed after these procedures. The cases were studied clinically and hematologically and the fatal cases pathologically. In those patients whose bloodgroup type was not O and who received bone marrow from O donors, the O type cells were found in peripheral blood by a differential agglutination method for days following the infusion of bone marrow. Changes in O type cell counts were studied comparatively in various recipients (those with radiation-destroyed marrow, pathologic marrow of hypoplastic type, and apparently normal marrow). Cell count-time curves were analyzed by comparison with hypothetical curves obtained by calculations based on the assumption that the marrow cells divided and matured in the body of recipients at a normal physiologic rate. The results revealed that O type cells in recipients with depleted marrow and pathologic marrow of hypoplastic type increased 1-3 weeks after the infusion of marrow and inincrease continued 2-3 weeks thereafter and then decreased. The absolute number of the O type cells was 15 x 10/sup 4//mm/sup 3/ when about 2 x 10/sup 9/ marrow cells were infused, i.e., the number of the O type cells corresponded to about 100 times the calculated number 1-2 weeks after the marrow infusion. In the blood of cases with normal marrow, O type cells showed no significant increase. The degree of temporary take of infused bone marrow could be evaluated directly by this method (O type bone marrow infusion). (BBB)

• Research Organization: Tokushima Univ., Japan
• NSA Number: NSA-18-003544
• OSTI ID: 4127669
• Journal Information: Nippon Ketsueki Gakkai Zasshi (Japan), Journal Name: Nippon Ketsueki Gakkai Zasshi (Japan) Vol. Vol: 24; ISSN NKGZA
• Country of Publication: Country unknown/Code not available
• Language: Japanese

Related Subjects

ADRENAL GLANDS
ANEMIA
ANTIMITOTIC DRUGS
BIOLOGY AND MEDICINE
BLOOD CELLS
BONE MARROW
CANCER
COBALT 60
DISEASES
DRUGS
GAMMA RADIATION
HORMONES
LEUCOCYTES
LEUKEMIA
MAN
MEDICINE
METASTASES
QUANTITY RATIO
RADIOTHERAPY
THERAPY
TRANSPLANTS
X RADIATION