Cytotoxic and mutagenic effects of carcinogenic aromatic amides and polycyclic hydrocarbons and ultraviolet irradiation in normally repairing and repair-deficient (xeroderma pigmentosum) diploid human skin fibroblasts

Conference · Wed Jan 01 00:00:00 EST 1975

OSTI ID:4126503

Maher, V M; McCormick, J J; Hanawalt, P C ^[1]

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1. ed.

The cloning ability of fibroblasts taken from a xeroderma pigmentosum patient proved 2.5 to 3.5 times more sensitive to the cytotoxic effect of active derivatives of carcinogens or to uv irradiation than that of normal cells. They also exhibited a corresponding 2.5- to 3.5-fold greater increase in the frequency of induced mutations to 8-azaguanine resistance per survivor, which might have been expected since these XP cells exhibit less than 20 percent of the DNA- repairing capacity of the normal cells following exposure to such DNA-damaging agents. (auth)

• Research Organization: Michigan Cancer Foundation, Detroit
• NSA Number: NSA-33-012244
• OSTI ID: 4126503
• Resource Relation: Conference: DNA repair processes conference, Squaw Valley, California, USA, Feb 1974; Other Information: See CONF-740231--PB. Orig. Receipt Date: 30-JUN-76; Related Information: Molecular mechanisms for repair of DNA. Part B
• Country of Publication: United States
• Language: English

Related Subjects

N48210* -Life Sciences-Radiation Effects on Cells- External Source
560121* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Cells-External Source
*AMIDES- TOXICITY
*AROMATICS- TOXICITY
*CARCINOGENS- TOXICITY
*DNA- BIOLOGICAL REPAIR
*FIBROBLASTS- BIOLOGICAL RADIATION EFFECTS
*HYDROCARBONS- TOXICITY
*MUTATIONS- RADIOINDUCTION
MAN
PATIENTS
SKIN DISEASES
ULTRAVIOLET RADIATION