Ca--DTPA toxicity in the mouse fetus
It has been shown in previous work that Ca-DTPA is only slightly more effective than Zn-DTPA in the removal of actinide metals from experimental animals but that treatment with the calcium chelate can have toxic side effects. An investigation of the effect of Ca-DTPA and Zn-DTPA injections of female mice on their developing fetuses is reported. Injection schedule and birth data are tabulated. There were no viable offspring produced by dams injected daily with 2.9 mmole Ca-DTPA/kg; with an injection dosage of 0.36 mmole Ca-DTPA/kg fecundities were near normal, as were fetal development and growth rates during the lactation period. On the other hand by using the same levels of dosage with zinc trisodium chelate no apparent harm was suffered by either mothers or pups. It is concluded that while both the calcium and zinc salts of DTPA are highly effective chelating agents, the demonstrated fetal toxicity of the calcium chelate indicates that Ca-DTPA should not be given to a woman who might be pregnant. If chelation therapy is warranted, the much safer Zn-DTPA, rather than Ca-DTPA, should be used. (UK)
- Research Organization:
- Univ. of Utah, Salt Lake City
- NSA Number:
- NSA-33-009630
- OSTI ID:
- 4125732
- Journal Information:
- Health Phys., v. 29, no. 5, pp. 780-782, Journal Name: Health Phys., v. 29, no. 5, pp. 780-782; ISSN HLTPA
- Country of Publication:
- United Kingdom
- Language:
- English
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*FETUSES-- BIOLOGICAL EFFECTS
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
CALCIUM COMPOUNDS
COMPARATIVE EVALUATIONS
MICE
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
SODIUM COMPOUNDS
ZINC COMPOUNDS