Intrarenal distribution of $sup 125$I-albumin in the Syrian hamster

Journal Article · Tue Dec 31 23:00:00 EST 1974 · Pfluegers Arch., v. 354, no. 3, pp. 241-248

DOI:https://doi.org/10.1007/BF00584647· OSTI ID:4124246

Moeller, P; Taugner, R

The intrarenal distribution of radioiodinated human serum albumin ($sup 125$RISA) after intravenous injection was studied in Syrian hamsters by scintillation counting and frozen section autoradiography. Frozen section autoradiography indicated that the distribution of radioalbumin in the renal cortex of the Syrian hamster is limited mainly to the kidney vessels, being expecially noticeable in the glomerular capillaries. Toward the papilla increasingly greater (mainly extratubular) activity could be observed not only intravascularly but also interstitially. In the cortex of the rat kidney, on the other hand, radioactive albumin was accumulated (probably by filtration and reabsorption) predominantly in the proximal tubular epithelium. Within 30 min the kidneys of the rat excreted more than 10 times as much $sup 125$I than the hamster kidneys. These results (substantially less cortical accumulation and urinary excretion or radioalbumin in the Syrian hamster) indicate that, in contrast to the rat, obviously much less albumin is filtered (and then accumulated by proximal reabsorption) by the Syrian hamster glomeruli. This suggests that the Syrian hamster kidney is more suitable than the rat kidney for determining the interstitial, cortical, albumin space. (orig./WL)

• Research Organization: Heidelberg Univ. (F.R. Germany). 1. Physiologisches Inst.
• NSA Number: NSA-33-009690
• OSTI ID: 4124246
• Journal Information: Pfluegers Arch., v. 354, no. 3, pp. 241-248, Journal Name: Pfluegers Arch., v. 354, no. 3, pp. 241-248; ISSN PFLAB
• Country of Publication: Germany
• Language: English

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