Serial Irradiation of Mouse Tumours: Some Changes in Histology and Cytology
Histological and cytological comparisons were made on parent and serially irradiated lines of sarcoma 37 and two homologous tumors in RIII strain inbred mice. The two homologous tumors showed no marked changes after serial irradiation. Regions of increased anaplasia were apparent in the adenocarcinoma MV212 after serial irradiations. Histological changes were apparent in the cortex of sarcoma 37 tumors subjected to sublethal doses at each irradiation stage. In this same line a proportional occurred in certain cells having a characteristic nuclear morphology. Both of these changes appeared to be progressive during the establishment of the irradiated line and were not altered by sub-line passage without further irradiation treatment. The significance of these changes is discussed in relation to radiosensitivity, cell degenera tion, and invasive properties. A correlation is suggested between nuclear morphology and ploidy.
- Research Organization:
- Mount Vernon Hospital, Northwood, Middx., Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-001263
- OSTI ID:
- 4123377
- Journal Information:
- British Journal of Cancer, Journal Name: British Journal of Cancer Journal Issue: 2 Vol. 14; ISSN 0007-0920
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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