EFFECT OF DOSE-RATE AND FRACTIONATION OF X-RAY DOSE ON ACUTE LETHALITY IN MICE

Journal Article · Sat Oct 01 04:00:00 EDT 1960 · Intern. J. Radiation Biol.

DOI:https://doi.org/10.1080/09553006014550501· OSTI ID:4123350

Brown, J A.H.; Corp, M J; Westgarth, D R

The difference in x-ray dosage needed to kill mice acutely when the exposure varied from 12 min to 6 hr and the dose rate from 3 to 55 rads/min was studied. The effect of giving the dose divided into 72 separate fractions was also described. The dose needed to kill depends almost wholly on the over-all exposure time. i.e., for continuous radiation the actual exposure time or for fractionated doses the time between the start of the first dose and the end of the last one. The longer the duration of exposure the larger the dose required; changes in dose rate and number of fractions appeared to be of no consequence. Two different multiple-regression equations. expressed in terms of dose and time only, provide an equally effective description of the response. Possible mathematical models leading to each of these equations were suggested. lt seems clear, however that experimental data of the kind reported here cannot provide critical tests of current ideas about the rate of recovery from radiation. (auth)

• Research Organization: Medical Research Council, Radiobiological Research Unit, Harwell, Berks, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-001268
• OSTI ID: 4123350
• Journal Information: Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
LETHAL DOSE
MATHEMATICS
MICE
RADIATION DOSES
RADIATION EFFECTS
RECOVERY
X RADIATION