IMMUNOLOGIC RESPONSE TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN LETHALLY IRRADIATED MICE TREATED WITH BONE MARROW

Journal Article · Sat Oct 01 04:00:00 EDT 1960 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4123311

Uphoff, D E; Haas, V H

ABS>Lymphocytic choriomeningitis-immune, nonimmune, and lymphocytic choriomeningitis-carrier mice were exposed to lethal total-body x irradiation and protected by an inoculation of marrow from either immune or nonimmune donors. Subsequent challenge of the surviving chimeras with potent homologous virus established that, under the conditions of these experiments, immunity was a function of the host and not of the transplanted tissue. These observations and those of other workers may be explained by assuming that the preirradiation immunologic response of the chimeras usually persists after irradiation, but that immunologically competent marrow may either react against the host or impose its own immunologic mechanism upon the host. (auth)

• Research Organization: National Cancer Inst., Bethesda, Md.; and National Inst. of Allergy and Infectious Diseases, Bethesda, Md.
• NSA Number: NSA-15-001275
• OSTI ID: 4123311
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 25; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
IMMUNITY
INFECTIONS
LIFETIME
LYMPH SYSTEM
LYMPHOCYTES
MEDICINE
MICE
RADIATION INJURIES
RADIATION PROTECTION
VIRUSES
X RADIATION