RESPIRATION AND GLYCOLYSIS IN X-IRRADIATED EHRLICH MOUSE ASCITES CARCINOMA CELLS

Journal Article · Sun Dec 01 00:00:00 EST 1963 · Radiation Res.

DOI:https://doi.org/10.2307/3571350· OSTI ID:4122953

Coe, E L; Garcia, E N; Ibsen, K H; McKee, R W

>Ehrlich ascites tumor cells exposed in vitro at a concentration of 80 mg dry-weight equivalent per milliliter to 500 to 4000 r showed no significant alterations in glycolytic or oxidative metabolism relative to unirradiated controls. At 8000 r, however, there was some indication of damage to glycolysis. Cells irradiated with 500 to 8000 r all showed an increase in ATP concentration, the increase being greater at the higher levels of radiation. These observations are discussed with relation to the fact that cells irradiated with 2000 to 4000 r no longer kill their hosts, but instead grow briefly and then regress, producing an immunity toward the nonirradiated ascites cell. (auth)

• Research Organization: Univ. of California, Los Angeles
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-005089
• OSTI ID: 4122953
• Journal Information: Radiation Res., Vol. Vol: 20; Other Information: Orig. Receipt Date: 31-DEC-64
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ATP
CANCER
CYTOLOGY
EHRLICH ASCITES
ENZYMES
IMMUNITY
METABOLISM
OXYGEN
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
SUGARS
TRANSPLANTS
VARIATIONS
WEIGHT
X RADIATION