Organization of the deoxyribonucleic acid replicating system in mammalian cells as revealed by the use of x-radiation and bromuracil deoxyriboside
Results are reported from studies of the effects of x radiation on the synthesis of desoxyribonucleic acid in HeLa and hamster cells in tissue culture. The incorporation of tritium-labeled thymidine and bromouracil desoxyriboside, an analog of thymidine, was allowed for various time periods before or after irradiation at various doses. Three different methods of DNA extraction were used. Possible mechanisms for radioinduced inhibition of DNA synthesis are discussed. The concept of a very-high molecular weight DNA is discussed in relation to the data obtained.
- Research Organization:
- Ames Research Center, Moffett Field, Calif.
- NSA Number:
- NSA-18-011756
- OSTI ID:
- 4121452
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 201
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
PREPARATION OF TRITIUM-LABELED THYMIDINE AND ITS USE FOR THE STUDY, BY THE RADIOAUTOGRAPHIC METHOD, OF THE SYNTHESIS OF DEOXYRIBONUCLEIC ACID IN CELLS BEING CULTURED
Inhibition of deoxyribonucleic acid synthesis and replicon elongation in mammalian cells exposed to methyl methanesulfonate
A STUDY OF THE PENETRATION OF MAMMALIAN CELLS BY DEOXYRIBONUCLEIC ACIDS
Technical Report
·
Fri Oct 30 23:00:00 EST 1959
·
OSTI ID:4293600
Inhibition of deoxyribonucleic acid synthesis and replicon elongation in mammalian cells exposed to methyl methanesulfonate
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Mol. Pharmacol.; (United States)
·
OSTI ID:5884167
A STUDY OF THE PENETRATION OF MAMMALIAN CELLS BY DEOXYRIBONUCLEIC ACIDS
Technical Report
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Thu Dec 31 23:00:00 EST 1959
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OSTI ID:4104974
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BROMINE COMPLEXES
DNA
HAMSTERS
LABELLED COMPOUNDS
METABOLISM
NUCLEIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
SEPARATION PROCESSES
THYMIDINE
TRITIUM
URACILS
X RADIATION
ANIMAL CELLS
ANIMALS
BROMINE COMPLEXES
DNA
HAMSTERS
LABELLED COMPOUNDS
METABOLISM
NUCLEIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
SEPARATION PROCESSES
THYMIDINE
TRITIUM
URACILS
X RADIATION