COUMARIN DERIVATIVES FOR MEDICINAL PURPOSES. XV. SYNTHESIS OF 6- CHLOROCOUMARIN-Cl$sup 36$ AND ITS DISTRIBUTION IN VIVO

Journal Article · Sun Sep 01 04:00:00 EDT 1963 · Yakugaku Zasshi (Japan)

OSTI ID:4119727

Kitagawa, H; Riitiro, I; Noguti, T

Methods are outlined for the synthesis of Cl/sup 36/- labeledaminocoumarin hydrochloride-Cl/sup 36/. Diazotization was carried out with sodium nitrite and 3N hydrochloric acid in ether or with isoamyl nitrite in dioxane. The diazonium tion of hydrogen chloride gas) or with copper powder in acetone. The product had an activity of 3.2 x 10/sup 6/ cpm/ millimole. Oral administration of 6-chlorocoumarin-Cl/sup 36/ to a rabbit resulted in decrease of urine on the 2nd and 3rd day but the amount of urine returned to normal on the 4th day. Radioactivity decreased progressively irrespective of urinary excretion and 22.8% of the original radioactivity was found in the urine excreted during 96 hr after administration. 6-Chlorocoumarin-Cl/sup 36/ was distributed in various organs and the incorporrtion ratio per gram of the organ decreased in the order: small intestine, kidney, pancreas, spleen, skeletal muscle, heart, bladder, and brain. Incorporation ratio to total weight of organs decreased in the order: kidney, pancreas, liver, heart, spleen, and brain. (BBB)

• Research Organization: National Heart Inst., Bethesda, Md.
• NSA Number: NSA-18-012026
• OSTI ID: 4119727
• Journal Information: Yakugaku Zasshi (Japan), Journal Name: Yakugaku Zasshi (Japan) Vol. Vol: 83; ISSN YKKZA
• Country of Publication: Country unknown/Code not available
• Language: Japanese

Related Subjects

ACETONE
BRAIN
CHEMICAL REACTIONS
CHEMISTRY
CHLORINATED HYDROCARBONS
CHLORINE 36
COPPER
COUMARIN
DECONTAMINATION
DIAZOTIZATION
DIOXANE
DRUGS
ETHERS
GLANDS
HEART
HYDROCHLORIC ACID
INTESTINE
KIDNEYS
LABELLED COMPOUNDS
MUSCLES
NITRITES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXYGEN COMPOUNDS
PANCREAS
POWDERS
PREPARATION
RABBITS
RADIATION EFFECTS
SODIUM COMPOUNDS
SOLUTIONS
SPLEEN
URINE