A STUDY ON THE INDUSTRIAL CHROMIUM POISONING (AN EXPERIMENTAL STUDY WITH $sup 51$Cr/)
Journal Article
·
· Osaka City Medical Journal (Japan)
OSTI ID:4035276
Tracer chromium-51 was administered through mouth and trachea, to gninea pigs, and a comparative study was performed concerning its invasion into a living body, its absorption, excretion, distribution and accurnulation. The concentration of Cr/sup 51/ in blood is lower in the case of oral administration than in the case of tracheal administration. In oral adrninistration, Cr/sup 51/ decreased comparatively quickly, but, in the case of tracheal administration, it was detected even ten days after administration. In both cases the movement of Cr/sup 51/ to the bcne and teeth was slight. In both cases, the concentration of Cr/sup 51/ in the liver was high in the initial stage of experiment. It decreased in the spleen, and it tended to increase in the latter period. The concentration of Cr/sup 51/ in the kidneys was higher in the case of tracheal administration. The amount in the stomach and intestines was large at the initial stage of experirnent, then gradually decreased. The amount in the brains and muscles was extremely snnall in both cases, and it quickly disappeared. In the case of oral admistration, the amount of Cr/sup 51/ excreted in feces was very large, while that in urine was small. During the period of observation for ten days after adminlstration, the total amount excreted was 90.6%, that intc urine and feces was 18.7% and 79.8%, respectively. The reason for the large excretion into feces is that a large amount simply passed through the digestive organs. In tracheal admninistration, the amount of excretion in feces was far less than that into urine. As observed for ten days after administration, the total amount excreted was 95.0%, consisting of 67.0% into urine and 26.0% into feces. The amount of Cr/sup 51/ absorbed in the body was 0.6% and 1.3%, respectively, in the case of oral and tracheal administration (N.W.R.)
- Research Organization:
- Osaka City Univ. Medical School
- NSA Number:
- NSA-15-023264
- OSTI ID:
- 4035276
- Journal Information:
- Osaka City Medical Journal (Japan), Journal Name: Osaka City Medical Journal (Japan) Vol. Vol: 6: No. 1; ISSN OCMJA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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