CATALASE LEVELS AND RADIOSENSITIVITY OF LIVER CELLS
Following exposure of regenerating liver to 580 r x nediition at a time when the average amount of DNA per cell nucleus has reached 1.6 times the normal value, the usual increase in number of cell nuclei was retarded while the average amount of DNA per cell nucleus continued to rise until it approached twice the normal value. Cell division was delayed for an unusually long period following irradiation at this stage of development. On the other hand, there was no corresponding increase during liver regeneration in the effects of high doses of x radiation on diphosphopyridine nucleotide concentrations in the liver. Although the liver catalase concentration decreased during liver regeneration, inhibition of catalase activity failed to Increase the radiosensitivity of liver cells. (auth)
- Research Organization:
- Atomic Energy of Canada Ltd., Chalk River, Ont.
- NSA Number:
- NSA-15-003884
- OSTI ID:
- 4118014
- Report Number(s):
- AECL-1119
- Journal Information:
- Can. J. Biochem. and Physiol., Journal Name: Can. J. Biochem. and Physiol. Vol. Vol: 38, No. 12
- Country of Publication:
- Canada
- Language:
- English
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