INVESTIGATION OF THE MOLECULAR NATURE OF CELLULAR RADIOSENSITIVITY (in French)
The locus of cellular radiosensitivity was studied in rats and mice by measuring the uptake of radioactive precursors in nucleic acids at various intervals after irradiation of partially hepatectomized animals. During hepatic regeneration, biochemical events that lead to cell division follow one another in a well-defined sequence. Accordingly, active synthesis of nuclear RNA is quickiy followed by cytoplasmic RNA synthesis, which, in turn, is followed by formation of new proteins, among which are thymo 5-phosphate kinase and polymerase. Following incorporation of precursors either in vivo in various subcellular preparations of regenerating liver of irradiated animals or, in vitro in various subcellular preparations of regenerating liver obtained from irradiated animals, it was possible to demonstrate that x irradiation inhibits DNA synthesis in regenerating liver. The results suggest that the radiosensitive target is present during interphase and that the latent cellular damage becomes apparent only when cell divisions are induced in the liver. (TCO)
- Research Organization:
- Univ. of Wisconsin, Madison
- NSA Number:
- NSA-17-027140
- OSTI ID:
- 4697630
- Journal Information:
- Laval Medical (Canada), Journal Name: Laval Medical (Canada) Vol. Vol: 34; ISSN LAMEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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