IMMUNOLOGICALLY COMPETENT CELLS IN ADULT MOUSE LIVER: STUDIES WITH PARENT- TO-HYBRID RADIATION CHIMERAS

Journal Article · Tue Nov 01 04:00:00 EST 1960 · Proc. Soc. Exptl. Biol. Med.

DOI:https://doi.org/10.3181/00379727-105-26113· OSTI ID:4116282

Cudkowicz, G; Cosgrove, G E

Implantation into irradiated hybrids of viable liver cells from adult donor mice of the parental strains caused a wasting disease followed by death in over 90% of the recipients. This foreign liver disease occurred after a sublethal dose of radiation was given to the recipients or after thal dose followed by infusion of isologous hone marrow. It did not occur in nonirradiated recipients but occurred in only 26% of sublethally irradiated F/sup 1/ hybrids infused with isologous bone marrow. In a strain combination in which the F/sup 1/ hybrid was homozygous at the H-2 locus, and the parents should therefore have been antigenetically relatively compatible, the foreign liver disease occurred late after treatment and was enhanced by the hybrid. It was shown that radiation dose and liver cell dose were interrelated factors in determining the development of the disease. Deaths are ascribed to an in vivo immunologic reaction after antibody production by the grafted parental cells against F/sup 1/ antigens. Nevertheless, there is evidence of a possible immune response by the F/sup 1/ hybrid against the parent. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-003900
• OSTI ID: 4116282
• Journal Information: Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 105
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
BONE MARROW
DISEASES
GENETICS
IMMUNITY
LETHAL DOSE
LIVER
MICE
RADIATION INJURIES
TRANSPLANTS