Bone-marrow Mitotic Inhibition induced by Local Splenic X-irradiation
X-irradiations were carried out on surgically exteriorized spleens of lead-shielded rabbits, and the resulting hematological changes were studied in the blood and bone marrow. The results show that 48 to 66 hr after 300 r x- irradiation of the spleens, reticulocytopenia results, indicating erythropoietic inhibition. Bone-marrow activity also decreases 20 hr after splenic irradiation, and the post-irradiation mitotic index is 45% lower than the preirradiation index. Similar experiments on splenectomized rabbits did not show any such changes. Experiments utilizing splenectomies at different intervals after splenic irradiation showed that only the animals with intact spleens at least 2 hr after irradiation showed erythropoietic inhibition. The isolation of an antimitotic factor from irradiated spleens is reported.
- Research Organization:
- University Hospital, Geneva
- NSA Number:
- NSA-18-008172
- OSTI ID:
- 4113296
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 200
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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