KINETICS OF STEROID EFFECTS ON Ca$sup 47$ DYNAMICS IN DOGS WITH THE ANALOG COMPUTER. PART II
The effect of adrenal steroids on the distribution of intravenously administered Ca/sup 47/ was studied by use of an analog computer. A distributive model, consistent with the literature, was programmed on the computer and was shown to be in agreement with the fecal and blood serum levels of Ca/sup 47/. Adrenal steroid effects can be assigned to a decrease in the Ca capacity of the metabolic pool with respect to the Ca capacity of the blood and to enhanced transfer of Ca to the gastrointestinal tract. This distributive model wvas correlated with the empirical equations computer-derived for fitting the Ca/sup 47/ data. Blood levels and fecal excretion of Ca/sup 47/ are enhanced by steroid and depressed on recovery. It was definitely proved that when the quasi equilibria of radioactive Ca among blood, soft tissues, metabolic pool, and contents of the gastrointestinal tract have born achieved, the relatively slow fecal elimination of Ca/sup 47/ at an apparently linear rate is doubled by the steroid administered and relapses to the control values on recovery. The phenomena are consistent with the hypothesis that adrenal steroids not only inhibit the entry of endogenous Ca into the bone and enhance its sccretion into the gastrointestinal tract but also promote the resorption of Ca from bone. (auth)
- Research Organization:
- Univ. of Florida, Gainesville
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-006601
- OSTI ID:
- 4112642
- Journal Information:
- Journal of Pharmaceutical Sciences (U.S.), Journal Name: Journal of Pharmaceutical Sciences (U.S.) Vol. Vol: 52; ISSN JPMSA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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