FACTORS ELABORATED BY ANIMAL TISSUES WHICH STIMULATE RATE OF REGENERATION OF HEMATOPOIETIC ORGANS OF ANIMALS EXPOSED TO TOTAL BODY IRRADIATION WITH GAMMA RAYS. Technical Progress Report
Technical Report
·
OSTI ID:4106625
A number of biological substances were evaluated for their protective effects against radiation injuries in rats. Materials screened include rat peritoneal exudate cells administered intravenously; various pituitary extracts, supernatant fluids from cultures of liver and adrenal cells; adrenal extracts; steroid compounds; 18 nucleic acid precursors; orotic acid; 4-amino-5-imidazole carboxamideHCl; and glutamine. Data are tabulated. Extensive data are included on the protective effects of bone-marrow therapy against radiation injuries. Mechanisms whereby intravenous bone marrow is therapeutically beneficial in radiation injury are discussed. Data on bone-marrow therapy are correlated with nucleic aeid precursor data. The effects of radiation dose, dose protective material, and route of administration of protective material on results are discussed. The pattern of mortality in treated and untreated rats following exposure to 1000 r whole-body irradiation is deseribed. Data are summarized from a study of the degree of bone-marrow damage as reflected by the total nucleated cell count in the irradiated femurs from subtotally-shielded rats. The data are consistent with the concept that bone marrow is more radioresistant in vivo than is generally considered. Results are reported from a study which indicates there is no specific relations between the small intestine and bone marrow. Data are ineluded from studies on the effect of rat bone marrow on heinatopoietic recovery in sublethally irradiated monkeys and in autologously treated, lethally irradiated monkeys. (C.H.)
- Research Organization:
- Parke, Davis and Co., Detroit
- NSA Number:
- NSA-15-008521
- OSTI ID:
- 4106625
- Report Number(s):
- TID-11729
- Country of Publication:
- United States
- Language:
- English
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