GENETIC RADIOSENSITIVITY OF SPECIFIC POST-DICTYATE STAGES IN MOUSE OOCYTES
The induction of dominant lethals after x irradiation of dictyate, later meiotic stages, and the pronuclear storage after fertilization was compared using the technique of induced ovulation in mice. The injection of gonadotrophins ensures that the time at which the synchronously dividing oocytes reach any particular meiotic stage is accurately known. Embryonic lethality up to 13.5 days was studied after 0, 100, and 200 r acute x irradiation. Metaphase I, anaphase I and metaphase II were the most sensitive stages, with LD/sub 50/'s of about 120, 130, and 170 r respectively. The dictyate and pronuclear stages were much less sensitive, with LD/sub 50/'s in the region of 500 r, and sensitivity rose steeply during prophase I. Numbers of corpora lutea decreased with irradiation, the decrease being greatest with irradiation at metaphase I and anaphase I. The ovulation of large numbers of eggs, which increased the preimplantation loss of embryos above normal, and the low luteal counts probably masked lethality to some extent. Results generally agree well with those reported in a number of plant and animal species. (auth)
- Research Organization:
- National Inst. for Medical Research, London and Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-008154
- OSTI ID:
- 4104743
- Journal Information:
- Genetical Research (England), Vol. Vol: 4; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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