EXPERIMENTAL STUDIES ON THE ELIMINATION OF RADIOIODINE FROM THE BODY

Journal Article · Sun Dec 01 04:00:00 EST 1963 · Health Physics (England)

DOI:https://doi.org/10.1097/00004032-196312000-00051· OSTI ID:4103474

Graul, E H; Stumpf, W E; Frerichs, G

An experimental study involving more than 250 guinea pigs was conducted in order to develop a therapeutic schedule for emergency treatment of acute radioiodine exposure. The effects of KClO/sub 4/, Iodine, TSH, and the diuretic hydrochlorthiazid, administered to animals in varying dosages at several tinre intervals following I/sup 131/ uptake, were examined on thyroid and whole-body levels of I/sup 131/. KClO/sub 4/ proved more effective than iodine in blocking the uptake of I/sup 131/ by thyroid. TSH treatment is contraindicated 24 hr after I/sup 131/ administration. A combined treatment with TSH and KClO/sub 4/ gives optimal results at time intervals exceeding 24 hr after administration of I/ sup 131/. It is proposed that gastric lavage (with injection of KCIO/sub 4/) be used within the first few hours following I/sup 131/ exposure. Ingestion of salivary secretions must also be avoided. (auth)

• Research Organization: Universitat, Marburg, Eng.
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-008090
• OSTI ID: 4103474
• Journal Information: Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 9; ISSN HLTPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDS
BIOLOGY AND MEDICINE
BODY
CHLORIC ACID
DRUGS
EFFICIENCY
GLANDS
GUINEA PIGS
HETEROCYCLICS
HORMONES
INTESTINE
IODINE
IODINE 131
LIQUIDS
MEASURED VALUES
MEDICINE
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
POTASSIUM COMPOUNDS
QUANTITY RATIO
SALIVARY GLANDS
STOMACH
THYROID
TSH
VARIATIONS