A STUDY OF THE PHYSIOLOGICAL FUNCTION AND HISTOLOGICAL CHANGES OF THYROIDS IRRADIATED WITH RADIOACTIVE IODINE. Progress Report and Proposal for Continued Research October 1, 1959-October 1, 1960
Progress is reported in studies on the physiological and morphological effects of I/sup 131/ radiation on the thyroid. Data are included on the physiological changes produced in human thyroids after the administration of therapeutic doses of radioactive iodine. Serial quantitative chromatograms on the blood of 115 patients were studied. During the first few days the observations essentially reflect unaltered function of the thyroid, but with the passage of time the observations reflect the effects of radiation. The changing patterns of iodinated compounds in the blood, alterations in rate of return of the radioactivity to the thyroid, and the subsequent testing of the functional capacity of the gland permit an analysis of the effects of radiation. Preliminary results are reported from combined acute and chronic experiments in rats on the effects of various doses of I/sup 131/ at various time intervals and with and without thiouracil. Tritiated iodine was used in studies on the effects of I/sup 131/ on the uptake of thymidine by nuclei of thyroid cells. Measurements were also made of the levels of desoxyribonucleic acid in individual cells at intervals of 5 to 90 days after the administration of various doses of I/ sup 131/. (C.H.)
- Research Organization:
- Western Reserve Univ., School of Medicine. Cleveland
- NSA Number:
- NSA-15-010695
- OSTI ID:
- 4094902
- Report Number(s):
- WRU-400
- Country of Publication:
- United States
- Language:
- English
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