AN AUTORADIOGRAPHIC STUDY OF THE EPIPHYSEAL CARTILAGE IN PAPAIN-TREATED RABBITS AFTER ADMINISTRATION OF RADIOSULPHATE
Results are reported from an autoradiographic study of epiphyseal cartilage using radiosulfate in rabbits treated with papain. With the aid of the stripping film technique, a detailed study was made on the cellular level, with special consideration to early changes. The results of the investigation confirmed the conclusion based on results from earlier studies that papain acts directly upon the cartilage cells. The findings observed may result from damage to the cell or to its permeability. The results of the investigation also suggest that the effect of papain continues for about 20 hr after injection, followed by a reparative phase. Seven days after injection of papain the cartilage cells and matrix appear to function normally as regards their uptake of S/sup 35/, although considerable morphologic changes persist. The chondroitin sulfate, which at the time of papain injection is located in the metaphyseal cartilage remnants enclosed by bone, does not appear to be affected by papain. It would seem that bone deposits or calcification afford a protection against the effect of papain. (auth)
- Research Organization:
- Univ. of Uppsala
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-010649
- OSTI ID:
- 4094192
- Journal Information:
- Acta Pathologica et Microbiologica Scandinavica (Denmark) Divided into Acta Pathol. Microbiol. Scand., Sect. A and Acta Pathol. Microbiol. Scand., Sec, Journal Name: Acta Pathologica et Microbiologica Scandinavica (Denmark) Divided into Acta Pathol. Microbiol. Scand., Sect. A and Acta Pathol. Microbiol. Scand., Sec Vol. Vol: 49; ISSN APMIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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