Theory of the induction of bone cancer by radiation: a preliminary report. I. A three-stage alpha particle model and the data for radium in man

Technical Report · Thu Jan 01 04:00:00 EST 1976

DOI:https://doi.org/10.2172/4088509· OSTI ID:4088509

Marshall, J. H.; Groer, P. G.

A model which involves two events of initiation and one of promotion yields an acceptable fit to the induction of osteosarcoma in the human radium cases. A three-dimensional system of analysis shows that the model fits the whole dose-time-response surface, the cumulative incidence versus radium intake, and the time distribution of tumors at each intake level. The two initiation events are produced in an endosteal cell by two alpha particles. The promotion event is related to the local rate of bone remodeling; being unrelated to radiation it provides an explanation for latent period. A competition between initiation and killing of endosteal cells provides an explanation for the plateau of tumor rate both in time and in level of intake for average skeletal doses greater than 1000 rads. (auth)

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• Sponsoring Organization: US Energy Research and Development Administration (ERDA)
• NSA Number: NSA-33-020552
• OSTI ID: 4088509
• Report Number(s): ANL--75-60(Pt.2)
• Country of Publication: United States
• Language: English

Related Subjects

*BONE TISSUES-- RADIATION DOSES
*OSTEOSARCOMAS-- RADIOINDUCTION
560162* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Animals
ALPHA PARTICLES
ANIMAL CELLS
BEAGLES
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
DATA
MAN
N48610 --Life Sciences--Radionuclide Effects (Internal Source)--Man
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
NEOPLASMS
RADIUM 226