Metabolism and effects of uranium in animals
Conference
·
OSTI ID:4082778
This paper summarizes the results of animal experiments that are the foundation of our current understanding of the biological behavior or uranium. Topics discussed include: metabolism including biological transport, excretion, deposition and retention in kidney and bone; absorption after parenteral administration, feeding, inhalation, or application to skin or eye; maternal transfer; and clearance of inhaled compounds from the lung. Acute chemical toxicity, including mechanism of action and effects on renal tubules; effects on blood and urine chemistry; acute mortality after parenteral administration or application to skin or eye; and the acute toxicity of $sup 233$U. Chemical toxicity after prolonged exposure, including mortality; kidney function and pathology during chronic ingestion or inhalation; and tolerance to uranium poisoning. Radiation effects, including induction of bone tumors by soluble $sup 232$U or $sup 233$U; subacute mortality from $sup 233$U; pneumonia and fibrosis in lung and induction of lung tumors by inhaled oxides of $sup 235$U or natural U. (auth)
- Research Organization:
- Univ. of California, Berkeley; Energy Research and Development Administration, Washington, D.C. (USA)
- NSA Number:
- NSA-33-020570
- OSTI ID:
- 4082778
- Report Number(s):
- ERDA--93; CONF-750445--
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*LABORATORY ANIMALS-- PATHOLOGICAL CHANGES
*NEOPLASMS-- RADIOINDUCTION
*URANIUM 232-- BIOLOGICAL RADIATION EFFECTS
*URANIUM 233-- BIOLOGICAL RADIATION EFFECTS
*URANIUM 235-- BIOLOGICAL RADIATION EFFECTS
*URANIUM-- HEALTH HAZARDS
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
BIOLOGICAL EFFECTS
BONE TISSUES
CHEMICAL REACTION KINETICS
CHRONIC INTAKE
INGESTION
INHALATION
INTERNAL IRRADIATION
KIDNEYS
LUNGS
METABOLISM
MORTALITY
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
RADIONUCLIDE KINETICS
RETENTION FUNCTIONS
SKIN ABSORPTION
TISSUE DISTRIBUTION
TOXICITY
*NEOPLASMS-- RADIOINDUCTION
*URANIUM 232-- BIOLOGICAL RADIATION EFFECTS
*URANIUM 233-- BIOLOGICAL RADIATION EFFECTS
*URANIUM 235-- BIOLOGICAL RADIATION EFFECTS
*URANIUM-- HEALTH HAZARDS
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
BIOLOGICAL EFFECTS
BONE TISSUES
CHEMICAL REACTION KINETICS
CHRONIC INTAKE
INGESTION
INHALATION
INTERNAL IRRADIATION
KIDNEYS
LUNGS
METABOLISM
MORTALITY
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
RADIONUCLIDE KINETICS
RETENTION FUNCTIONS
SKIN ABSORPTION
TISSUE DISTRIBUTION
TOXICITY