IMMUNIZATION IN SCHISTOSOMIASIS BY PREVIOUS EXPOSURE TO HOMOLOGOUS AND HETEROLOGOUS CERCARIAE BY INOCULATION OF PREPARATIONS FROM SCHISTOSOMES AND BY EXPOSURE TO IRRADIATED CERCARIAE
A review on immmnization in schistosomiasis indicates that immunization is certainly possible. Mice can be protected much more readily against S. japonicum than against S. mansoni. However, the Rhesus monkeys develop an acquired resistance to S. mansoni. Rats can also be easily protected with worm homogenates of S. mansoni. It has also been observed that a previous exposure to a Formosan heterologous strain of S. japonicum induced a greater degree of resistance than exposures to the Japanese homologous strains. The least significant degree of acquired immunity is induced by vaccination with worm homogenates or worm products and with the transfer of serum from immune to normal animals. It was also indicated that exposure of monkeys to irradiated cercariae induced a marked resistance to a subsequent challenge of nonattenuated cercaria of S. mansoni. 67 references are included. (P.C.H.)
- Research Organization:
- Walter Reed Army Medical Center. Inst. of Research, Washington, D.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-009806
- OSTI ID:
- 4073057
- Journal Information:
- Annals of the New York Academy of Sciences (U.S.), Vol. Vol: 113; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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