THE EFFECT OF DEUTERIUM OXIDE ON ASCITES TUMOR GROWTH IN MICE

Journal Article · Fri Nov 25 04:00:00 EST 1960 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1960.tb39107.x· OSTI ID:4070917

Finkel, A J; Czajka, D M

The growth of Hrebs-24 ascites tumors in mice was appreciably depressed by the presence of deuterium in the body fluids in concentrations ranging from 13 to 32%. Measurement of the glutamic oxalacetic transaminase (GO-T) levels revealed that with increasing deuteration there was a progressive elevation of serum GO-T in tumor-bearing mice and an even more rapid rise of ascitic plasma GO- T. These data suggest that deuteration of the organism leads to tumor-cell injury with resulting release of GO-T into the ascitic fluid, whence it is carried into the general circulation. The notion that deuterium injures and possibly destroys mouse ascites tumor cells is supported, in part, by the terminal increase in the incidence of eosinstainable tumor cells, and, in part, by the absence of any striking difference in mitotic index of deuterated and nondeuterated tumor cells. These conclusions properly apply to transplantable mouse ascites tumors, and they may or may not bs applicable to other biological material. (auth)

• Research Organization: Argonne National Lab., Ill.
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-012682
• OSTI ID: 4070917
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 84; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CYTOLOGY
DEUTERIUM
DEUTERIUM COMPOUNDS
ENZYMES
MICE
RADIATION INJURIES
TRANSPLANTS
TUMORS