RADIOISOTOPE STUDY OF INTESTINAL ABSORPTION IN HOCKWORM INFECTED PATIENTS. Final REport, September 1, 1961-August 30, 1963
Technical Report
·
OSTI ID:4070146
Studies on the morphology of the peripheral blood and bone naarrow, intestInal absorption tests, and jejunum biopsy were performed in 22 subjects harboring heavy hookworm infection. Fat absorption, measured both chemically and with oleic acid marked with /sup 131/I, was normal in all patients but three, who showed slight increase of excretion; d-xylose was poorly absorbed in one out of 18 cases tested; serum vitamin B/sub 12/ concentration was significantly diminished, and the Schilling test performed in eight patients showed 24-hr urinary excretions of B/sub 12/ /sup 58/Co over 10%. Morphological changes in the peripheral blood and bone marrow suggestive of either vitamin B/sub 12/ or folic acid deficiency were seen in five cases. In four cases in which serum folate activity was determined values below 4.6 m mu g/ml of serum were found. Jejunum biopsy, performed in 18 cases, showed only slight nonspecific changes in 14 cases. Of the other four, one showed frank atrophy of the mucosa, a second flattening of the mucosal surface and fusion of the villi, and the other two marked infiltration. especially around the crypts. The results indicate that hookworm infection per se, without the association of other factors such as malnutrition and other parasitic irfections, does not as a rule lead to histological changes in the mucosa which might cause malabsorption of nutrients. (auth)
- Research Organization:
- Fundacion Luis Roche. Instituto Venezolano de Investigaciones Cientificas, Caracas
- NSA Number:
- NSA-18-021724
- OSTI ID:
- 4070146
- Report Number(s):
- TID-20404
- Country of Publication:
- United States
- Language:
- English
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