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CHEMICAL SYNTHESIS OF TRITIUM-LABELED LINOLEIC ACID

Journal Article · · Biochemistry (U.S.)
DOI:https://doi.org/10.1021/bi00891a017· OSTI ID:4067997

Tritium-labeled linoleic acid with a specific activity of 357 mC/mmole was obtained in 70% yield from totally synthesized octadeca-9,12-diynoic acid. A source of 1 curie of tritium gas was used to semihydrogenate the diacetylenic acid in the presence of Lindlar's catalyst. Chemical and radiochemical purity of the final product were assessed by chromatographic methods. Evidence from mild oxidation indicated that the tritium-labeled linoleic acid was prepared with a specificity of greater than 95% of the activity at the

Research Organization:
Univ. of Illinois, Urbana
Sponsoring Organization:
USDOE
NSA Number:
NSA-18-016070
OSTI ID:
4067997
Journal Information:
Biochemistry (U.S.), Journal Name: Biochemistry (U.S.) Vol. Vol: 3; ISSN BICHA
Country of Publication:
Country unknown/Code not available
Language:
English

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